atm signaling pathway
| PAG Title | atm signaling pathway |
| PAG ID | WAG000628 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | The ataxia telangiectasia-mutated gene (ATM) encodes a protein kise that acts as a tumor suppressor. ATM activation by ionizing radiation damage to D stimulates D repair and blocks progression through the cell cycle. Mutation of the ATM gene causes the disease ataxia telangiectasia which which involves an inherited predisposition to some cancers. To play this role ATM interacts with a broad network of proteins, including checkpoint factors (chk1, chk2), tumor suppressors (p53 and BRCA), D repair factors (RAD50, RAD51, GADD45), and other sigling molecules (c-Abl and NF-kB). In addition to regulating D repair and the cell cycle, ATM can also trigger apoptosis in radiation treated cells. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 2,452 |
| Information Content | Rich |
| Other IDs | |
| Base PAG ID | WAG000628 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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