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atm signaling pathway

PAG Title atm signaling pathway
PAG ID WAG000628
Type P
Source Link BioCarta
Publication Reference NA
PAG Description The ataxia telangiectasia-mutated gene (ATM) encodes a protein kise that acts as a tumor suppressor. ATM activation by ionizing radiation damage to D stimulates D repair and blocks progression through the cell cycle. Mutation of the ATM gene causes the disease ataxia telangiectasia which which involves an inherited predisposition to some cancers. To play this role ATM interacts with a broad network of proteins, including checkpoint factors (chk1, chk2), tumor suppressors (p53 and BRCA), D repair factors (RAD50, RAD51, GADD45), and other sigling molecules (c-Abl and NF-kB). In addition to regulating D repair and the cell cycle, ATM can also trigger apoptosis in radiation treated cells.
Species Homo sapiens
nCoCo Score 2,452
Base PAG ID WAG000628
Human Phenotyte Annotation
Curator PAGER curation team
Curator Contact PAGER-contact@googlegroups.com
Gene ID Gene symbol Gene name RP_score
Gene A Gene B Source SCORE

Gene A Gene B Mechanism Source
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